Exploring Protein Kinase Inhibitors
نویسندگان
چکیده
منابع مشابه
Endogenous Protein Kinase Inhibitors
A thermostable inhibition of ATP:protein phosphotransferase (EC 2.7.1.37) (protein kinase) which is present in crude tissue extracts has been resolved by gel chromatography (Sephadex G-100) into two molecular forms. These two forms will be referred to as type I and type II inhibitor. The type I inhibitor (M, = 24,000) is specific for CAMP-dependent protein kinase and corresponds to the inhibito...
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Background: The stomach is an infrequent site of breast cancer metastasis. It may prove very difficult to distinguish a breast cancer metastasis to the stomach from a primary gastric cancer on the basis of clinical, endoscopic, radiological and histopathological features. It is important to make this distinction as the basis of treatment for breast cancer metastasis to the stomach is usually wi...
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Several mechanisms may influence the enhanced glucose uptake in cancer cells, including upregulation of glucose transporters, increase in the hexokinase activity and the protein kinase B, also called Akt, which appears to play key role in the control of glucose metabolism together with proteins which are involved in the signal cascade pathway, such as the mammalian target of rapamycin (mTOR). I...
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Introduction: Protein kinase causes many diseases, including cancer; therefore, inhibiting them plays an important role in the treatment of many diseases. Traditional discovery inhibitors of this enzyme is a time-consuming and costly process. Finding a reliable computer-aided drug discovery tools which can detect the inhibitors will reduce the cost. In this study, it is attempted to separate ki...
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Most of the signal transduction pathways are mediated by protein kinases regulating every aspect of cell function. Mutations which deregulate their expression or their function or both result in cancers. Therefore, protein kinase inhibitors has become the focus of development of new therapies for cancer. Almost all 120 protein tyrosine kinases are involved in signaling, whereas only a handful o...
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ژورنال
عنوان ژورنال: Pancreas
سال: 2012
ISSN: 0885-3177
DOI: 10.1097/mpa.0b013e318230f71a